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Article

Inhibition of human immunodeficiency virus reactivation from latency by a tat transdominant negative mutant.

Journal of medical virology - 1 Dec 1993

Balboni P G, Bozzini R, Zucchini S, Marconi P C, Grossi M P, Caputo A, Manservigi R, Barbanti-Brodano G

Abstract excerpt

A BK virus (BKV) expression vector, specific for human cells, was engineered to express antisense human immunodeficiency virus type 1 (HIV-1) tat cDNA (tat-AS) or a tat mutant in cysteine 22 (tat22). Cysteine residues in the cysteine-rich domain of tat are necessary for tat transactivation of the HIV-1 long terminal repeat (LTR). Both the AS tat and the tat mutant significantly inhibited transactivation by tat...

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PMID: 8106862
DOI: 10.1002/jmv.1890410406

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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