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Article

Inhibition of human immunodeficiency virus reactivation from latency by a tat transdominant negative mutant.

Journal of medical virology - 1 Dec 1993

Balboni P G, Bozzini R, Zucchini S, Marconi P C, Grossi M P, Caputo A, Manservigi R, Barbanti-Brodano G

Abstract excerpt

A BK virus (BKV) expression vector, specific for human cells, was engineered to express antisense human immunodeficiency virus type 1 (HIV-1) tat cDNA (tat-AS) or a tat mutant in cysteine 22 (tat22). Cysteine residues in the cysteine-rich domain of tat are necessary for tat transactivation of the...

Topics

BK Virus
Blotting, Northern
CD4 Antigens
Cell Line, Transformed
Gene Products, tat
Genes, tat
Genetic Vectors
HIV-1
Humans
Mutagenesis, Site-Directed
Mutation
RNA, Antisense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Viral

Transcription, Genetic

Virus Activation

Virus Latency

tat Gene Products, Human Immunodeficiency Virus

Source

Identifiers

PMID: 8106862
DOI: 10.1002/jmv.1890410406

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8106862-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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