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Article

Functional comparison of the basic domains of the Tat proteins of human immunodeficiency virus types 1 and 2 in trans activation.

Journal of virology - 1 Apr 1992

Elangovan B, Subramanian T, Chinnadurai G

Abstract excerpt

The trans-activator Tat proteins coded by human immunodeficiency virus type 1 (HIV-1) and HIV-2 appear to be similar in structure and function. However, the Tat protein of HIV-2 (Tat2) activates the HIV-1 long terminal repeat (LTR) less efficiently than Tat1 (M. Emerman, M. Guyader, L. Montagnier, D. Baltimore, and M. A. Muesing, EMBO J. 6:3755-3760, 1987). To determine the functional domain of Tat2 which...

Topics

Amino Acid Sequence
Cell Line
Cloning, Molecular
Gene Products, tat
HIV-1
Molecular Sequence Data
Mutation
Precipitin Tests
Sequence Alignment
Transcriptional Activation
tat Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 1548750
DOI: 10.1128/JVI.66.4.2031-2036.1992
PMCID: PMC288992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1548750-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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