Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of HIV-1 Tat proteins mutated in the transactivation domain for prophylactic and therapeutic application.

Vaccine - 14 May 2001

Betti M, Voltan R, Marchisio M, Mantovani I, Boarini C, Nappi F, Ensoli B, Caputo A

Abstract excerpt

Previous work from our group showed that genetic immunization of mice with HIV-1 tat genes (tat22 and tat22/37), encoding Tat proteins mutated in the transactivation domain and lacking Tat-transactivating activity, evoke an immune response to wild-type Tat, both humoral and cellular. In the present work we report that the mutated Tat proteins localize within the cells, are released and taken up by the cells in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIDS Vaccines
Share to Gene Products, tat

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Viral

Share to HIV Infections

Share to Recombinant Fusion Proteins

Share to tat Gene Products, Human Immunodeficiency Virus

Share to Transcriptional Activation

Source

Identifiers

PMID: 11348705
DOI: 10.1016/s0264-410x(01)00067-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of HIV-1 Tat proteins mutated in the transactivation domain for prophylactic and therapeutic application.PMID 11348705Read ↗

Design and characterization of an HIV-1 Tat mutant: inactivation of viral and cellular functions but not antigenicity.Semantic proximity Read ↗

HIV-1 Tat protein as a potential AIDS vaccine.Semantic proximity Read ↗

Role of HIV-1 Tat Protein Interactions with Host Receptors in HIV Infection and PathogenesisSemantic proximity Read ↗

Inhibition of HIV-1 replication and reactivation from latency by tat transdominant negative mutants in the cysteine rich region.Semantic proximity Read ↗

Functional comparison of the basic domains of the Tat proteins of human immunodeficiency virus types 1 and 2 in trans activation.Semantic proximity Read ↗

Functions of Tat: the versatile protein of human immunodeficiency virus type 1Semantic proximity Read ↗

Tat mutations in an African cohort that do not prevent transactivation but change its immunogenic properties.Semantic proximity Read ↗

Does the human immunodeficiency virus Tat trans-activator contain a discrete activation domain?Semantic proximity Read ↗

Human immunodeficiency virus type 2 (HIV-2) trans-activator (Tat): functional domains and the search for trans-dominant negative mutants.Semantic proximity Read ↗

HIV Tat protein requirements for transactivation and repression of transcription are separable.Semantic proximity Read ↗

Construction and characterization of a potent HIV-2 Tat transdominant mutant protein.Semantic proximity Read ↗

Transactivation and signaling functions of Tat are not correlated: biological and immunological characterization of HIV-1 subtype-C Tat proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.