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Article

An in vivo replication-important function in the second coding exon of Tat is constrained against mutation despite cytotoxic T lymphocyte selection.

The Journal of biological chemistry - 7 Nov 2003

Smith Stephen M, Pentlicky Sara, Klase Zachary, Singh Mahender, Neuveut Christine, Lu Chun-yi, Reitz Marvin S, Yarchoan Robert, Marx Preston A, Jeang Kuan-Teh

Abstract excerpt

Human and simian immunodeficiency virus (HIV/SIV) Tat proteins are specified by two coding exons. Tat functions in the transcription of primate lentiviruses. A plethora of in vitro data currently suggests that the second coding exon of Tat is largely devoid of function. However, whether the second exon of Tat contributes functionally to viral pathogenesis in vivo remains unknown. To address this question...

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Source

Identifiers

PMID: 12947089
DOI: 10.1074/jbc.M307546200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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