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Article

Microglial response to amyloid plaques in APPsw transgenic mice.

The American journal of pathology - 1 Jan 1998

Frautschy S A, Yang F, Irrizarry M, Hyman B, Saido T C, Hsiao K, Cole G M

Abstract excerpt

Microglial activation is central to the inflammatory response in Alzheimer's Disease (AD). A recently described mouse line, Tg(HuAPP695.K670N/M671L)2576, expressing human amyloid precursor protein with a familial AD gene mutation, age-related amyloid deposits, and memory deficits, was found to develop a significant microglial response using Griffonia simplicifolia lectin or phosphotyrosine probe to identify...

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PMID: 9422548
PMCID: PMC1858113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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