Article
Mutations in p53, p53 protein overexpression and breast cancer survival.
Journal of cellular and molecular medicine - 1 Sept 2009
Rossner Pavel, Gammon Marilie D, Zhang Yu-Jing, Terry Mary Beth, Hibshoosh Hanina, Memeo Lorenzo, Mansukhani Mahesh, Long Chang-Min, Garbowski Gail, Agrawal Meenakshi, Kalra Tara S, Gaudet Mia M, Teitelbaum Susan L, Neugut Alfred I, Santella Regina M
Abstract excerpt
p53 is an important tumour suppressor gene that encodes p53 protein, a molecule involved in cell cycle regulation and has been inconsistently linked to breast cancer survival. Using archived tumour tissue from a population-based sample of 859 women diagnosed with breast cancer between 1996 and 1997, we determined p53 mutations in exons 5-8 and p53 protein overexpression. We examined the association of p53...
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