Article
Prognostic significance of p53 gene alterations in node-negative breast cancer.
Breast cancer research and treatment - 1 Jan 1993
Elledge R M, Fuqua S A, Clark G M, Pujol P, Allred D C, McGuire W L
Abstract excerpt
UNLABELLED: Mutations in the p53 gene can play a role in the transformation of normal to malignant cells. Because these mutations are more frequently reported later in the course of transformation, their presence could reflect a greater malignant potential of the tumor and, thus, an increased probability of metastasis and recurrence after local therapy. In a pilot study using single-stranded conformation...
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