TP53 and MYC gene alterations independently predict poor prognosis in breast cancer patients.

doi:10.1002/(SICI)1098-2264(199607)16:3<170::AID-GCC3>3.0.CO;2-W

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Article

TP53 and MYC gene alterations independently predict poor prognosis in breast cancer patients.

Genes, chromosomes & cancer - 1 Jul 1996

Berns E M, Klijn J G, Smid M, van Staveren I L, Look M P, van Putten W L, Foekens J A

Abstract excerpt

We intended to establish the frequency of exon-specific TP53 gene alterations and the relation to patient and tumor characteristics and clinical outcome of patients with breast cancer. By using polymerase chain reaction-single-strand conformation polymorphism analysis (PCR-SSCP) and sequencing techniques, TP53 gene alterations were found in 59 (32%) of the 187 samples studied. Most of the TP53 changes (37%) were...

Topics

Adult
Age Factors
Aged
Aged, 80 and over
Analysis of Variance
Base Sequence
Breast Neoplasms
Disease-Free Survival
Female
Genes, myc
Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Middle Aged

Molecular Sequence Data

Mutation

Polymorphism, Single-Stranded Conformational

Receptors, Estrogen

Receptors, Progesterone

Source

Open in PubMed

Identifiers

PMID: 8814449
DOI: 10.1002/(SICI)1098-2264(199607)16:3<170::AID-GCC3>3.0.CO;2-W

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