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Article

Prognostic significance of mutations to different structural and functional regions of the p53 gene in breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2000

Powell B, Soong R, Iacopetta B, Seshadri R, Smith D R

Abstract excerpt

Alteration to the p53 tumor suppressor gene is associated with more aggressive disease in breast cancer, as evidenced by the shortened survival of patients with mutation. Data obtained from in vitro experiments suggest that mutations to different structural and functional domains of p53 may give rise to different effects on its biological activities, notably transactivational and apoptotic properties. We...

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PMID: 10690522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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