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Article

A single point mutation activates the Moloney murine leukemia virus long terminal repeat in embryonal stem cells.

Journal of virology - 1 Sept 1991

Grez M, Zörnig M, Nowock J, Ziegler M

Abstract excerpt

The expression of Moloney murine leukemia virus (Mo-MuLV) and Mo-MuLV-derived vectors is restricted in undifferentiated mouse embryonal carcinoma and embryonal stem (ES) cells. We have previously described the isolation of retroviral mutants with host range properties expanded to embryonal cell lines. One of these mutants, the murine embryonic stem cell virus (MESV), is expressed in ES cell lines. Expression of...

Topics

Base Sequence
Cell Line
Cloning, Molecular
DNA, Viral
DNA-Binding Proteins
Enhancer Elements, Genetic
Gene Expression Regulation, Viral
Molecular Sequence Data
Moloney murine leukemia virus
Mutation
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repetitive Sequences, Nucleic Acid

Stem Cells

Transcription, Genetic

Source

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Identifiers

PMID: 1870196
DOI: 10.1128/JVI.65.9.4691-4698.1991
PMCID: PMC248924

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1870196-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A single point mutation activates the Moloney murine leukemia virus long terminal repeat in embryonal stem cells.PMID 1870196Read ↗

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