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Article

Silencing of mouse Aprt is a gradual process in differentiated cells.

Molecular and cellular biology - 1 Jul 2003

Yates Phillip A, Burman Robert, Simpson James, Ponomoreva Olga N, Thayer Mathew J, Turker Mitchell S

Abstract excerpt

Mouse Aprt constructs that are highly susceptible to DNA methylation-associated inactivation in embryonal carcinoma cells were transfected into differentiated cells, where they were expressed. Construct silencing was induced by either whole-cell fusion of the expressing differentiated cells with embryonal carcinoma cells or by treatment of the differentiated cells with the DNA demethylating agent...

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Identifiers

PMID: 12808089
DOI: 10.1128/MCB.23.13.4461-4470.2003
PMCID: PMC164859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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