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Antiviral Defence Mechanisms during Early Mammalian Development

24 Jan 2024

Abstract excerpt

The type-I interferon (IFN) response constitutes the major innate immune pathway against viruses in mammals. Despite its critical importance for antiviral defence, this pathway is inactive during early embryonic development. There seems to be an incompatibility between the IFN response and pluripotency, the ability of embryonic cells to develop into any cell type of an adult organism. Instead, pluripotent cells...

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PMID: 38399949
DOI: 10.3390/v16020173

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