Article
Site-directed mutagenesis on the m2 muscarinic acetylcholine receptor: the significance of Tyr403 in the binding of agonists and functional coupling.
Molecular pharmacology - 1 Dec 1997
Vogel W K, Sheehan D M, Schimerlik M I
Abstract excerpt
The first step in the transmembrane signal mediated by G protein-coupled receptors is binding of agonist to receptors at the cell surface. The mechanism of the resulting receptor activation is not clear, but models based on the ternary complex model are capable of explaining most of the observati...
Topics
- Acetylcholine
- Animals
- Binding Sites
- CHO Cells
- Carbachol
- Cricetinae
- Cyclic AMP
- GTP-Binding Proteins
- Kinetics
- Muscarinic Agonists
- Muscarinic Antagonists
- Mutagenesis, Site-Directed
- Mutation
- Oxotremorine
- Receptor, Muscarinic M2
- Receptors, Muscarinic
- Tyrosine