Article
Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes.
The EMBO journal - 1 Dec 1990
Lechleiter J, Hellmiss R, Duerson K, Ennulat D, David N, Clapham D, Peralta E
Abstract excerpt
Relatively little is understood concerning the mechanisms by which subtypes of receptors, G proteins and effector enzymes interact to transduce specific signals. Through expression of normal, hybrid and deletion mutant receptors in Xenopus oocytes, we determined the G protein coupling characteris...
Topics
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Cloning, Molecular
- GTP-Binding Proteins
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Oocytes
- Pertussis Toxin
- Receptors, Cholinergic
- Recombinant Proteins
- Regulatory Sequences, Nucleic Acid
- Virulence Factors, Bordetella