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Article

Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes.

The EMBO journal - 1 Dec 1990

Lechleiter J, Hellmiss R, Duerson K, Ennulat D, David N, Clapham D, Peralta E

Abstract excerpt

Relatively little is understood concerning the mechanisms by which subtypes of receptors, G proteins and effector enzymes interact to transduce specific signals. Through expression of normal, hybrid and deletion mutant receptors in Xenopus oocytes, we determined the G protein coupling characteristics of the functionally distinct m2 and m3 muscarinic acetylcholine receptor (mAChR) subtypes and identified the...

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Identifiers

PMID: 2124972
DOI: 10.1002/j.1460-2075.1990.tb07888.x
PMCID: PMC552228

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