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Article

Molecular modeling of the M3 acetylcholine muscarinic receptor and its binding site.

Journal of biomedicine & biotechnology - 1 Jan 2012

Martinez-Archundia Marlet, Cordomi Arnau, Garriga Pere, Perez Juan J

Abstract excerpt

The present study reports the results of a combined computational and site mutagenesis study designed to provide new insights into the orthosteric binding site of the human M3 muscarinic acetylcholine receptor. For this purpose a three-dimensional structure of the receptor at atomic resolution was built by homology modeling, using the crystallographic structure of bovine rhodopsin as a template. Then, the...

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Identifiers

PMID: 22500107
DOI: 10.1155/2012/789741
PMCID: PMC3303834

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