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Article

Generation of an agonistic binding site for blockers of the M(3) muscarinic acetylcholine receptor.

The Biochemical journal - 15 May 2008

Thor Doreen, Schulz Angela, Hermsdorf Thomas, Schöneberg Torsten

Abstract excerpt

GPCRs (G-protein-coupled receptors) exist in a spontaneous equilibrium between active and inactive conformations that are stabilized by agonists and inverse agonists respectively. Because ligand binding of agonists and inverse agonists often occurs in a competitive manner, one can assume an overlap between both binding sites. Only a few studies report mutations in GPCRs that convert receptor blockers into...

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Identifiers

PMID: 18237275
DOI: 10.1042/bj20071366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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