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Article

Structure-function analysis of muscarinic receptors and their associated G proteins.

Life sciences - 1 Jan 1999

Kostenis E, Zeng F Y, Wess J

Abstract excerpt

Each member of the muscarinic receptor family (M1-M5) can interact only with a limited subset of the many structurally closely related heterotrimeric G proteins expressed within a cell. To understand how this selectivity is achieved at a molecular level, we have used the G(i/0)-coupled M2 and the Gq/11-coupled M3 muscarinic receptors as model systems. We developed a genetic strategy involving the coexpression of...

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Identifiers

PMID: 10069496
DOI: 10.1016/s0024-3205(98)00574-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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