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Article

Distinct Agonist Regulation of Muscarinic Acetylcholine M2-M3 Heteromers and Their Corresponding Homomers.

The Journal of biological chemistry - 5 Jun 2015

Aslanoglou Despoina, Alvarez-Curto Elisa, Marsango Sara, Milligan Graeme

Abstract excerpt

Each subtype of the muscarinic receptor family of G protein-coupled receptors is activated by similar concentrations of the neurotransmitter acetylcholine or closely related synthetic analogs such as carbachol. However, pharmacological selectivity can be generated by the introduction of a pair of mutations to produce Receptor Activated Solely by Synthetic Ligand (RASSL) forms of muscarinic receptors. These...

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Identifiers

PMID: 25918156
DOI: 10.1074/jbc.M115.649079
PMCID: PMC4505543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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