Article
Mutational analysis of muscarinic acetylcholine receptors: structural basis of ligand/receptor/G protein interactions.
Life sciences - 1 Jan 1993
Wess J
Abstract excerpt
Molecular cloning studies have revealed the existence of five molecularly distinct muscarinic acetylcholine receptors (m1-m5), which differ in their tissue distribution, ligand binding properties, and functional profiles. Structurally (and functionally), the muscarinic receptors are members of the superfamily of G protein-coupled receptors. A variety of different mutagenesis techniques have been used to study the...
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