Article
Mutational analysis of muscarinic acetylcholine receptors: structural basis of ligand/receptor/G protein interactions.
Life sciences - 1 Jan 1993
Wess J
Abstract excerpt
Molecular cloning studies have revealed the existence of five molecularly distinct muscarinic acetylcholine receptors (m1-m5), which differ in their tissue distribution, ligand binding properties, and functional profiles. Structurally (and functionally), the muscarinic receptors are members of th...
Topics
- Acetylcholine
- Amino Acid Sequence
- Animals
- Binding Sites
- GTP-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Receptors, Muscarinic
- Structure-Activity Relationship