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Article

Loss control of Mcm5 interaction with chromatin in cdc6-1 mutated in CDC-NTP motif.

DNA and cell biology - 1 Jul 2000

Feng L, Hu Y, Wang B, Wu L, Jong A

Abstract excerpt

Saccharomyces cerevisiae Cdc6 plays an essential role in establishing and maintaining the prereplicative complex (pre-RC) by interacting with the origin recognition complex (ORC) and associating with chromatin origins. These interactions are required to load minichromosome maintenance proteins (MCMs) and other initiator proteins onto replication origins. Although the temperature-sensitive cdc6 mutant, cdc6-1, has...

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Source

Identifiers

PMID: 10945234
DOI: 10.1089/10445490050085933

Genes

CDC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss control of Mcm5 interaction with chromatin in cdc6-1 mutated in CDC-NTP motif.PMID 10945234Read ↗

Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders.Semantic proximity Read ↗

Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants.Semantic proximity Read ↗

The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatin.Semantic proximity Read ↗

Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.Semantic proximity Read ↗

Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.Semantic proximity Read ↗

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.Semantic proximity Read ↗

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.Semantic proximity Read ↗

CDC28 phosphorylates Cac1p and regulates the association of chromatin assembly factor I with chromatin.Semantic proximity Read ↗

Schizosaccharomyces pombe replication protein Cdc45/Sna41 requires Hsk1/Cdc7 and Rad4/Cut5 for chromatin binding.Semantic proximity Read ↗

Functions of sensor 1 and sensor 2 regions of Saccharomyces cerevisiae Cdc6p in vivo and in vitro.Semantic proximity Read ↗

Cell Cycle Regulation of Human CDC6 ProteinSemantic proximity Read ↗

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.Semantic proximity Read ↗

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