Involvement of cdc2-mediated phosphorylation in the cell cycle-dependent regulation of p185neu.

doi:10.1038/sj.onc.1201442

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Article

Involvement of cdc2-mediated phosphorylation in the cell cycle-dependent regulation of p185neu.

Oncogene - 27 Nov 1997

Kiyokawa N, Karunagaran D, Lee E K, Xie Y, Yan D H, Hung M C

Abstract excerpt

We previously reported cell cycle-dependent negative regulation of p185neu (decreased tyrosine phosphorylation and kinase activity, with electrophoretic mobility retarded by serine/threonine phosphorylation) in M phase and the escape of mutation-activated p185neu* from this regulation. Our presen...

Topics

Animals
CDC2 Protein Kinase
Cell Cycle
Cell Transformation, Neoplastic
Cross-Linking Reagents
Dimerization
Mice
Mitosis
Mutation
Phosphorylation
Precipitin Tests
Receptor, ErbB-2

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