Article
Nucleophosmin protein expression level, but not threonine 198 phosphorylation, is essential in growth and proliferation.
Oncogene - 10 Sept 2009
Brady S N, Maggi L B, Winkeler C L, Toso E A, Gwinn A S, Pelletier C L, Weber J D
Abstract excerpt
Nucleophosmin (NPM), an oligomeric phosphoprotein and nucleolar target of the ARF tumor suppressor, contributes to several critical cellular processes. Previous studies have shown that the human NPM's phosphorylation by cyclin E-cyclin-dependent kinase 2 (cdk2) on threonine (Thr) 199 regulates its translocation from the centrosome during cell cycle progression. Given our previous finding that ARF directly binds...
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