Article
G2/M transition requires multisite phosphorylation of oncoprotein 18 by two distinct protein kinase systems.
The Journal of biological chemistry - 9 Jun 1995
Larsson N, Melander H, Marklund U, Osterman O, Gullberg M
Abstract excerpt
Oncoprotein 18 (Op18) is a conserved cytosolic protein that is a target for both cell cycle and cell surface receptor-regulated phosphorylation events. The four residues Ser16, Ser25, Ser38, and Ser63 are all subject to cell cycle-regulated phosphorylation. Ser25 and Ser38 are targets for cyclin dependent kinases (CDKs), while Ser16 and Ser63 are phosphorylated by an unidentified protein kinase. We have recently...
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