Article
The phenotype of a "Cdc2 kinase target site-deficient" mutant of oncoprotein 18 reveals a role of this protein in cell cycle control.
The Journal of biological chemistry - 2 Dec 1994
Marklund U, Osterman O, Melander H, Bergh A, Gullberg M
Abstract excerpt
Oncoprotein 18 (Op18) is a cytosolic protein that is expressed in all proliferating cells. This phosphoprotein is up-regulated in a variety of human neoplasm, and phosphorylation of its two Cdc2 kinase target sites, Ser-25 and Ser-38, fluctuates dramatically during the cell cycle. We have investi...
Topics
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- CDC2 Protein Kinase
- Cadmium
- Cell Cycle
- Cell Division
- Cell Line
- DNA Primers
- Edetic Acid
- Humans
- Leukemia, Erythroblastic, Acute
- Microtubule Proteins
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Oligodeoxyribonucleotides
- Phenotype
- Phosphoproteins