Article
Phosphorylation of Xenopus Cdc25C at Ser285 interferes with ability to activate a DNA damage replication checkpoint in pre-midblastula embryos.
Cell cycle (Georgetown, Tex.) - 1 Jan 2000
Bulavin Dmitry V, Demidenko Zoya N, Phillips Crissy, Moody Sally A, Fornace Albert J
Abstract excerpt
We have recently demonstrated that negative regulation of human Cdc25 protein phosphatases by phosphorylation at their 14-3-3 site can be antagonized through phosphorylation at an adjacent site in the -2 position.1 Based on structural homology for different Cdc25 phosphatases, a similar regulatory pathway also could be conserved in Xenopus embryos, where cell cycle checkpoints are not operational prior to the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.