Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein.

The Journal of biological chemistry - 18 Oct 2002

Geisen Christoph, Moroy Tarik

Abstract excerpt

We have previously shown that cyclin E can malignantly transform primary rat embryo fibroblasts in cooperation with constitutively active Ha-Ras. In addition, we demonstrated that high level cyclin E expression potentiates the development of methyl-nitroso-urea-induced T-cell lymphomas in mice. To further investigate the mechanism underlying cyclin E-mediated malignant transformation, we have performed a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CDC2-CDC28 Kinases
Share to Cyclin-Dependent Kinase 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Cyclin-Dependent Kinases

Share to Cyclin E

Share to G1 Phase

Share to Rats, Inbred F344

Share to Retinoblastoma-Like Protein p130

Source

Identifiers

PMID: 12149264
DOI: 10.1074/jbc.M205919200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein.PMID 12149264Read ↗

Kinase-independent function of E-type cyclins in liver cancerSemantic proximity Read ↗

Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancerSemantic proximity Read ↗

Cyclin E2, a Novel G1 Cyclin That Binds Cdk2 and Is Aberrantly Expressed in Human CancersSemantic proximity Read ↗

Cdk2 is Required for Breast Cancer Mediated by the Low-Molecular-Weight Isoform of Cyclin ESemantic proximity Read ↗

Promiscuity rules? The dispensability of cyclin E and Cdk2.Semantic proximity Read ↗

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis.Semantic proximity Read ↗

Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinomaSemantic proximity Read ↗

Rescue of cyclin D1 deficiency by knockin cyclin E.Semantic proximity Read ↗

Expression of cyclins E1 and E2 during mouse development and in neoplasiaSemantic proximity Read ↗

Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformationSemantic proximity Read ↗

Unmasking the redundancy between Cdk1 and Cdk2 at G2 phase in human cancer cell lines.Semantic proximity Read ↗

Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.