Article
Multisite M-phase phosphorylation of Xenopus Wee1A.
Molecular and cellular biology - 1 Dec 2005
Kim Sun Young, Song Eun Joo, Lee Kong-Joo, Ferrell James E
Abstract excerpt
The Cdk1 inhibitor Wee1 is inactivated during mitotic entry by proteolysis, translational regulation, and transcriptional regulation. Wee1 is also regulated by posttranslational modifications, and here we have identified five phosphorylation sites in the N-terminal domain of embryonic Xenopus Wee1A through a combination of mutagenesis studies and matrix-assisted laser desorption ionization-time of flight mass...
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