Article
Modulation of liver canalicular transport processes by the tyrosine-kinase inhibitor genistein: implications of genistein metabolism in the rat.
Hepatology (Baltimore, Md.) - 1 Dec 1997
Jäger W, Winter O, Halper B, Salamon A, Sartori M, Gajdzik L, Hamilton G, Theyer G, Graf J, Thalhammer T
Abstract excerpt
Rat liver cells express the multispecific organic anion transporter (cmoat, cmrp, mrp2) and P-glycoprotein (Pgp) in their canalicular membranes, proteins that are homologous to the multidrug-resistance related protein (MRP) and multidrug resistance (MDR) gene products in multidrug resistant tumor cells. We tested whether genistein, a modulator of drug resistance in tumor cells, affects biliary secretion of...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Anion Transport Proteins
- Bile
- Bilirubin
- Biological Transport
- Carrier Proteins
- Dose-Response Relationship, Drug
- Enzyme Inhibitors
- Genistein