Genistein metabolism in liver microsomes of Wistar and mutant TR(-)-rats.

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Article

Genistein metabolism in liver microsomes of Wistar and mutant TR(-)-rats.

Research communications in molecular pathology and pharmacology - 1 Apr 1998

Jäger W, Sartori M, Herzog W, Thalhammer T

Abstract excerpt

In mutant TR(-)-rats lack of the canalicular multispecific organic anion transporter prevents the biliary excretion of various phase II conjugates. In order to investigate whether this rat strain expresses high amounts of phase-I metabolic enzymes to compensate for the deficiency an in vitro study using liver microsomes of control and TR(-)-rats was conducted. While liver microsomes of non-mutant Wistar rats...

Topics

Animals
Anion Transport Proteins
Antineoplastic Agents
Blotting, Western
Carrier Proteins
Chromatography, High Pressure Liquid
Cytochrome P-450 Enzyme System
Dexamethasone
Genistein
In Vitro Techniques
Isoenzymes
Male
Microsomes, Liver
Mutation
NADP
Phenobarbital
Rats
Rats, Wistar

Source

Open in PubMed

Identifiers

PMID: 9644724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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