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Article

Characterization of multidrug resistance-associated protein 2 in the hepatocellular disposition of 4-hydroxynonenal.

Archives of biochemistry and biophysics - 15 Mar 2003

Reichard John F, Doorn Jonathan A, Simon Franz, Taylor Melinda S, Petersen Dennis R

Abstract excerpt

4-hydroxynonenal (4HNE) is a major product of peroxidative membrane lipid destruction and exerts a variety of deleterious actions through formation of covalent adducts with cellular nucleophiles. Consequently, a number of cellular enzyme systems exist that are capable of detoxifying this reactive aldehyde by oxidation, reduction, or conjugation with glutathione. In this investigation we characterize the multidrug...

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PMID: 12623073
DOI: 10.1016/s0003-9861(03)00002-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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