Biliary excretion of sulfobromophthalein compounds in normal and mutant Corriedale sheep. Evidence for a disproportionate transport defect for conjugated sulfobromophthalein.

Abstract excerpt

Biliary excretion of dye was evaluated in three normal and one mutant Corriedale sheep (characterized by depressed biliary transport of many organic anions) during infusion of unconjugated sulfobromophthalein (BSP) and its preformed glutathione conjugate (BSP-GSH). Maximal dye excretion rates in bile in normal sheep were higher when BSP-GSH rather than BSP was administered. In confirmation of earlier studies, dye...

Topics

• Animals
• Bile
• Bile Canaliculi
• Biological Transport
• Female
• Glutathione
• Kidney
• Mutation
• Sheep
• Sulfobromophthalein