Article
Effect of diethylmaleate on bile secretion and ultrastructural appearance of hepatocytes in normal rats and mutant rats with defective organic anion secretion.
Liver - 1 Feb 1996
Dumont M, D'Hont C, Feldmann G, Rogier E, Moreau A, Jansen P L, Erlinger S
Abstract excerpt
Diethylmaleate is an organic anion secreted into bile as a glutathione conjugate. Its transport by the hepatocyte is associated with dilatation of the Golgi apparatus and the appearance of small vesicles in the pericanalicular area. It has been speculated that the Golgi apparatus could play a rol...
Topics
- Animals
- Anions
- Bile
- Bile Acids and Salts
- Biological Transport
- Golgi Apparatus
- Linear Models
- Liver
- Male
- Maleates
- Microscopy, Electron
- Mutation
- Rats
- Rats, Mutant Strains
- Rats, Sprague-Dawley