Article
Impaired biliary excretion and whole body elimination of methylmercury in rats with congenital defect in biliary glutathione excretion.
Hepatology (Baltimore, Md.) - 1 Nov 1995
Ballatori N, Gatmaitan Z, Truong A T
Abstract excerpt
Biliary excretion of methylmercury, a major route of elimination of this toxic compound, was less than 2% of control in Eisai hyperbilirubinemic (EHBR) rats, a mutant Sprague-Dawley strain with a defect in biliary excretion of a variety of organic anions, including glutathione S-conjugates and re...
Topics
- Animals
- Bile
- Female
- Glutathione
- Half-Life
- Hyperbilirubinemia
- Mercury Radioisotopes
- Metabolism, Inborn Errors
- Methylmercury Compounds
- Mutation
- Rats
- Rats, Mutant Strains
- Rats, Sprague-Dawley
- Secretory Rate
