Hepatobiliary elimination of the peroxisome proliferator nafenopin by conjugation and subsequent ATP-dependent transport across the canalicular membrane.

doi:10.1016/0006-2952(94)90147-3

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Article

Hepatobiliary elimination of the peroxisome proliferator nafenopin by conjugation and subsequent ATP-dependent transport across the canalicular membrane.

Biochemical pharmacology - 15 Sept 1994

Jedlitschky G, Leier I, Böhme M, Buchholz U, Bar-Tana J, Keppler D

Abstract excerpt

Amphiphilic carboxylates acting as peroxisome proliferators and hypolipidemic drugs induce enzymes of peroxisomal lipid beta-oxidation, certain drug-metabolizing enzymes in the liver, and a number of additional proteins. The peroxisome proliferators represent a well-established class of non-genot...

Topics

Adenosine Triphosphate
Animals
Bile
Bile Canaliculi
Biological Transport
Glucuronates
Liver
Male
Mutation
Nafenopin
Rats
Rats, Wistar
Tritium

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