Article
Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia.
Pharmaceutical research - 1 Nov 1995
Takenaka O, Horie T, Kobayashi K, Suzuki H, Sugiyama Y
Abstract excerpt
PURPOSE: Previously, we found that the biliary excretion of the 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) glucuronide is severely impaired in Eisai hyperbilirubinemic rats (EHBR), while that of sulfate remains normal (Takenaka et al., J. Pharmacol. Exp. Ther.,...
Topics
- Adenosine Triphosphate
- Animals
- Benzothiazoles
- Bile
- Bile Canaliculi
- Biological Transport
- Cholagogues and Choleretics
- Cytosol
- Glucuronates
- Hyperbilirubinemia, Hereditary
- In Vitro Techniques
- Kinetics
- Lipoxygenase Inhibitors
- Liver
- Male
- Membranes
- Mutation
- Protein Binding