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Article

Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats.

American journal of physiology. Gastrointestinal and liver physiology - 1 Aug 2003

Crocenzi Fernando A, Mottino Aldo D, Cao Jingsong, Veggi Luis M, Pozzi Enrique J Sánchez, Vore Mary, Coleman Roger, Roma Marcelo G

Abstract excerpt

Endocytic internalization of the multidrug resistance-associated protein 2 (Mrp2) was previously suggested to be involved in estradiol-17beta-D-glucuronide (E217G)-induced cholestasis. Here we evaluated in the rat whether a similar phenomenon occurs with the bile salt export pump (Bsep) and the ability of DBcAMP to prevent it. E217G (15 micromol/kg i.v.) impaired bile salt (BS) output and induced Bsep...

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Identifiers

PMID: 12702498
DOI: 10.1152/ajpgi.00508.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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