Article
Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes.
The Journal of cell biology - 1 Oct 1995
Mayer R, Kartenbeck J, Büchler M, Jedlitschky G, Leier I, Keppler D
Abstract excerpt
We have previously shown that the multi-drug resistance protein (MRP) mediates the ATP-dependent membrane transport of glutathione S-conjugates and additional amphiphilic organic anions. In the present study we demonstrate the expression of MRP in hepatocytes where it functions in hepatobiliary e...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adenosine Triphosphate
- Adult
- Amino Acid Sequence
- Animals
- Anions
- Base Sequence
- Bile Canaliculi
- Biological Transport
- Blotting, Western
- Cell Membrane
- DNA, Complementary
- Drug Resistance, Multiple