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Article

Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes.

The Journal of cell biology - 1 Oct 1995

Mayer R, Kartenbeck J, Büchler M, Jedlitschky G, Leier I, Keppler D

Abstract excerpt

We have previously shown that the multi-drug resistance protein (MRP) mediates the ATP-dependent membrane transport of glutathione S-conjugates and additional amphiphilic organic anions. In the present study we demonstrate the expression of MRP in hepatocytes where it functions in hepatobiliary excretion. Analysis by reverse transcription-PCR of human and normal rat liver mRNA resulted in two expected cDNA...

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Identifiers

PMID: 7559771
DOI: 10.1083/jcb.131.1.137
PMCID: PMC2120605

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Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes.PMID 7559771Read ↗

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