Article
The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes.
Advances in enzyme regulation - 1 Jan 1997
Keppler D, König J, Büchler M
Abstract excerpt
The conjugate export pump in the hepatocyte canalicular membrane is, together with the ATP-dependent bile salt export pump, one of the two major pumps determining canalicular anion secretion and bile flow. The so-called bile salt-independent bile flow is largely driven by the cmrp/cmoat gene-enco...
Topics
- Adenosine Triphosphate
- Amino Acid Sequence
- Animals
- Anion Transport Proteins
- Carrier Proteins
- Cells, Cultured
- Cloning, Molecular
- Drug Resistance, Multiple
- Gene Expression Regulation
- Humans
- Jaundice, Chronic Idiopathic
- Leukotriene C4
- Liver
- Male
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Rats