Targeted disruption of an H3-IV/H3-V gene pair causes increased expression of the remaining H3 genes in the chicken DT40 cell line.

doi:10.1006/jmbi.1995.0387

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Article

Targeted disruption of an H3-IV/H3-V gene pair causes increased expression of the remaining H3 genes in the chicken DT40 cell line.

Journal of molecular biology - 21 Jul 1995

Takami Y, Takeda S, Nakayama T

Abstract excerpt

The chicken H3 gene family contains 12 members (H3-I to H3-XII). Nine of them belong to two major histone gene clusters, but the genomic locations of the others are unknown. In the DT40 chicken B cell line, H3-IV and H3-V, which are located in inverted orientation and share a 3'-untranslated region of 531 bp, produce about 24% of the steady-state level of total mRNAs from all the H3 genes. To study the nature of...

Topics

Alleles
Animals
Base Sequence
Cell Division
Chickens
Gene Expression
Gene Targeting
Heterozygote
Histones
Homozygote
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Probes

RNA, Antisense

RNA, Messenger

Ribonucleases

Transfection

Tumor Cells, Cultured

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PMID: 7616565
DOI: 10.1006/jmbi.1995.0387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7616565-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Targeted disruption of an H3-IV/H3-V gene pair causes increased expression of the remaining H3 genes in the chicken DT40 cell line.PMID 7616565Read ↗

Targeted disruption of H2B-V encoding a particular H2B histone variant causes changes in protein patterns on two-dimensional polyacrylamide gel electrophoresis in the DT40 chicken B cell line.Semantic proximity Read ↗

An approximately half set of histone genes is enough for cell proliferation and a lack of several histone variants causes protein pattern changes in the DT40 chicken B cell line.Semantic proximity Read ↗

Histone H1 variants play individual roles in transcription regulation in the DT40 chicken B cell line.Semantic proximity Read ↗

One allele of the major histone gene cluster is enough for cell proliferation of the DT40 chicken B cell line.Semantic proximity Read ↗

Targeted disruption of 01H1 encoding a particular H1 histone variant causes changes in protein patterns in the DT40 chicken B cell line.Semantic proximity Read ↗

Possible involvement of a ubiquitous and several distinct elements in the transcription regulation of the chicken H3 histone gene family.Semantic proximity Read ↗

N-terminal region, C-terminal region, nuclear export signal, and deacetylation activity of histone deacetylase-3 are essential for the viability of the DT40 chicken B cell line.Semantic proximity Read ↗

Presence of distinct transcriptional regulatory elements in the 5'-flanking region shared by the chicken H3 histone gene homopair.Semantic proximity Read ↗

Establishment of the DNA repair-defective mutants in DT40 cells.Semantic proximity Read ↗

A Drosophila melanogaster H3.3 cDNA encodes a histone variant identical with the vertebrate H3.3.Semantic proximity Read ↗

Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40.Semantic proximity Read ↗

Gene function analysis using the chicken B-cell line DT40.Semantic proximity Read ↗

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