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Article

Identification of genetic alterations in the TGFbeta type II receptor gene promoter.

Mutation research - 1 Nov 2001

Seijo E R, Song H, Lynch M A, Jennings R, Qong X, Lazaridis E, Muro-Cacho C, Weghorst C M, Muñoz-Antonia T

Abstract excerpt

Modifications in the control sequences of tumor suppressor genes have been found to play a role in the activation or inactivation of these genes and may play an important role in tumorigenesis. For example, hypermethylation of CpG islands and promoter polymorphisms have been found to be involved in transcriptional repression. A decrease in the levels of expression of one such tumor suppressor gene, the TGFbeta...

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Source

Identifiers

PMID: 11600128
DOI: 10.1016/s0027-5107(01)00217-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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