Article
Identification of genetic alterations in the TGFbeta type II receptor gene promoter.
Mutation research - 1 Nov 2001
Seijo E R, Song H, Lynch M A, Jennings R, Qong X, Lazaridis E, Muro-Cacho C, Weghorst C M, Muñoz-Antonia T
Abstract excerpt
Modifications in the control sequences of tumor suppressor genes have been found to play a role in the activation or inactivation of these genes and may play an important role in tumorigenesis. For example, hypermethylation of CpG islands and promoter polymorphisms have been found to be involved in transcriptional repression. A decrease in the levels of expression of one such tumor suppressor gene, the TGFbeta...
Topics
- Base Sequence
- Carcinoma, Squamous Cell
- Cell Line
- Cloning, Molecular
- DNA Primers
- Gene Expression
- Genes, Tumor Suppressor
- Head and Neck Neoplasms
- Humans
- Mutation
- Plasmids
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational