Article
Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells.
Cancer research - 15 Sept 1995
Garrigue-Antar L, Muñoz-Antonia T, Antonia S J, Gesmonde J, Vellucci V F, Reiss M
Abstract excerpt
In this study, we report the occurrence of missense mutations of the transforming growth factor beta (TGF beta) type II receptor gene in two human squamous head and neck carcinoma cell lines. Both mutations are G:C-->C:G transversions, which result in the replacement of a glutamic acid by a glutamine, and of an arginine by a proline residue, respectively. Moreover, both are located at highly conserved sites...
Topics
- Amino Acid Sequence
- Base Sequence
- Carcinoma, Squamous Cell
- Cells, Cultured
- Genes, Tumor Suppressor
- Head and Neck Neoplasms
- Humans
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Receptors, Transforming Growth Factor beta