A mutation in the transforming growth factor beta type II receptor gene promoter associated with loss of gene expression.

Article

A mutation in the transforming growth factor beta type II receptor gene promoter associated with loss of gene expression.

Cancer research - 1 Nov 1996

Muñoz-Antonia T, Li X, Reiss M, Jackson R, Antonia S

Abstract excerpt

Expression of transforming growth factor beta type II receptors (TbetaR-IIs) is either greatly decreased or absent in many tumors, implying that the loss of TbetaR-II function is one of the mechanisms leading to tumor development. In this report, we examine the expression of the TbetaR-II recepto...

Topics

Cell Line
Gene Expression
Humans
Mutation
Promoter Regions, Genetic
RNA, Messenger
Receptors, Transforming Growth Factor beta

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