Article
Analysis of TGF-beta type I receptor for mutations and polymorphisms in head and neck cancers.
Mutation research - 8 Aug 2001
Knobloch T J, Lynch M A, Song H, DeGroff V L, Casto B C, Adams E M, Alam K Y, Lang J C, Schuller D E, Weghorst C M
Abstract excerpt
Transforming growth factor-beta receptor (TbetaR)-dependent signals are critical for cell growth and differentiation and are often disrupted during tumorigenesis. The entire coding region of TbetaR-I and flanking intron sequences from 30 head and neck carcinomas were examined for alterations using "Cold" SSCP and direct sequencing. No somatic point mutations were found in the TbetaR-I gene. In contrast, 14...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.