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Article

Novel inactivating mutations of transforming growth factor-beta type I receptor gene in head-and-neck cancer metastases.

International journal of cancer - 1 Sept 2001

Chen T, Yan W, Wells R G, Rimm D L, McNiff J, Leffell D, Reiss M

Abstract excerpt

Carcinoma cell lines are frequently refractory to transforming growth factor-beta (TGF beta)-mediated cell cycle arrest. Whether and how TGF beta signaling is disrupted in the majority of human tumors, however, remains unclear. To investigate whether TGF beta signaling might be disrupted by inactivation of the key signaling molecule, the TGF beta type I (T beta R-I) receptor, and whether or not T beta R-I...

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Identifiers

PMID: 11477574
DOI: 10.1002/ijc.1381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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