Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic alterations in the transforming growth factor receptor complex in sporadic endometrial carcinoma.

Gene expression - 1 Jan 1999

Nakashima R, Song H, Enomoto T, Murata Y, McClaid M R, Casto B C, Weghorst C M

Abstract excerpt

Cellular responses to the transforming growth factor beta (TGFbeta) ligand, including inhibition of cell proliferation, are mediated by a heteromeric receptor complex composed of TGFbeta types I and II receptors (TbetaR-I and TbetaR-II). Loss of responsiveness to TGFbeta, attributed to inactivation of the TbetaR complex, has been implicated in the development of tumors in a number of human epithelial and lymphoid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activin Receptors, Type I
Share to Carcinoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endometrial Neoplasms

Share to Protein Serine-Threonine Kinases

Share to Receptor, Transforming Growth Factor-beta Type I

Share to Receptor, Transforming Growth Factor-beta Type II

Share to Receptors, Transforming Growth Factor beta

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 10947082
PMCID: PMC6157378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic alterations in the transforming growth factor receptor complex in sporadic endometrial carcinoma.PMID 10947082Read ↗

Structural alterations of transforming growth factor-beta receptor genes in human cervical carcinoma.Semantic proximity Read ↗

Inhibiting mutations in the transforming growth factor beta type 2 receptor in recurrent human breast cancer.Semantic proximity Read ↗

Aberrant expression and mutations of TGF-β receptor type II gene in endometrial cancerSemantic proximity Read ↗

Transforming growth factor-beta receptor type I gene is frequently mutated in ovarian carcinomas.Semantic proximity Read ↗

Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck.Semantic proximity Read ↗

Analysis of TGF-beta type I receptor for mutations and polymorphisms in head and neck cancers.Semantic proximity Read ↗

Expression of the type III TGF-β receptor is negatively regulated by TGF-βSemantic proximity Read ↗

Identification of genetic alterations in the TGFbeta type II receptor gene promoter.Semantic proximity Read ↗

Absence of mutations in the analysis of coding sequences of the entire transforming growth factor-beta type II receptor gene in sporadic human breast cancers.Semantic proximity Read ↗

Higher stromal expression of transforming growth factor-beta type II receptors is associated with poorer prognosis breast tumors.Semantic proximity Read ↗

Mutation of the transforming growth factor-beta type II receptor gene is a rare event in human sporadic gastric carcinomas.Semantic proximity Read ↗

A mutation in the transforming growth factor beta type II receptor gene promoter associated with loss of gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.