Article
Hypermodification and immune escape of an internally deleted middle-envelope (M) protein of frequent and predominant hepatitis B virus variants.
Virology - 5 Jan 2002
Tai Pei-Ching, Suk Fat-Moon, Gerlich Wolfram H, Neurath A Robert, Shih Chiaho
Abstract excerpt
Naturally occurring deletions within the human hepatitis B virus (HBV) preS2 region have frequently been identified in patients with hepatocellular carcinoma (HCC), while chronic carriers without cirrhosis and HCC contain no detectable preS2 deletion variants. We have characterized two different preS2 internal deletion variants from two patients. In addition to several weak phenotypes, our study revealed three...
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