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In vitro expression of precore proteins of hepatitis B virus subgenotype A1 is affected by HBcAg, and can affect HBsAg secretion.

Scientific reports - 14 Apr 2021

Deroubaix Aurélie, Kramvis Anna

Abstract excerpt

HBeAg, a non-particulate protein of hepatitis B virus (HBV), is translated from the precore/core region as a precursor, which is post-translationally modified. Subgenotype A1 of HBV, which is a risk factor for hepatocellular carcinoma (HCC), has unique molecular characteristics in the basic core promoter/precore regions. Carriers of A1 exhibit early HBeAg loss. We sought to further characterize the precore...

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Identifiers

PMID: 33854155
DOI: 10.1038/s41598-021-87529-9
PMCID: PMC8046783

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