Article
The pre-S region determines the intracellular localization and appearance of hepatitis B virus.
Hepatology (Baltimore, Md.) - 1 Aug 1999
Bock C T, Tillmann H L, Manns M P, Trautwein C
Abstract excerpt
The functional role of the hepatitis B virus (HBV) pre-S region for assembly and appearance of the virus is not completely understood. In this study, 3 natural-occurring mutants were investigated. Three mutants of the pre-S region-a point mutation in the CCAAT box (MUT1), a 6-bp deletion (MUT2) 3' of the CCAAT box, and a 153-bp deletion (MUT3) in the preS2 domain-were cloned alone or in combinations in...
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