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Article

Clinical Implications of HBV PreS/S Mutations and the Effects of PreS2 Deletion on Mitochondria, Liver Fibrosis, and Cancer Development.

Hepatology (Baltimore, Md.) - 1 Aug 2021

Liang Yuh-Jin, Teng Wei, Chen Chih-Li, Sun Cheng-Pu, Teng Rui-Dung, Huang Yen-Hua, Liang Kung-Hao, Chen Yi-Wen, Lin Chung-Chih, Su Chien-Wei, Tao Mi-Hua, Wu Jaw-Ching

Abstract excerpt

BACKGROUND AND AIMS: PreS mutants of HBV have been reported to be associated with HCC. We conducted a longitudinal study of the role of HBV preS mutations in the development of HCC, particularly in patients with chronic hepatitis B (CHB) having low HBV DNA or alanine aminotransferase (ALT) levels, and investigated the effects of secretion-defective preS2 deletion mutant (preS2ΔMT) on hepatocyte damage in vitro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33675094
DOI: 10.1002/hep.31789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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