Article
Functional analysis of complex hepatitis B virus variants associated with development of liver cirrhosis.
Gastroenterology - 1 Sept 2006
Märschenz Stefanie, Endres Anne-Sophie, Brinckmann Anja, Heise Tilman, Kristiansen Glen, Nürnberg Peter, Krüger Detlev H, Günther Stephan, Meisel Helga
Abstract excerpt
BACKGROUND & AIMS: Development of cirrhosis in renal transplant recipients with chronic hepatitis B is associated with the accumulation of complex hepatitis B virus (HBV) variants carrying deletions in the C gene and/or preS region and deletions/insertions in the core promoter. Here, we characterized for the first time the phenotype of these complex HBV variants. METHODS: Representative full-length genomes of the...
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